Due to German Covid restrictions the Reds will have to return to Budapest to host RB Leipzig.
Liverpool travelled to the Hungarian capital for a 2-0 first leg win as restrictions prevented the game being played in Leipzig.
The same regulations mean Leipzig could not return from the UK without entering into strict quarantine.
As a result, Uefa agreed that the match would have to be switched.
That means Liverpool will lose home advantage at Anfield.
Now it has been confirmed the second leg will also be played in the Puskas arena.
That makes it the first Champions League tie to see both matches played in the same stadium since AC Milan played Inter at the San Siro twice in the 2005 quarter-finals.