Juventus were beaten at home by Benfica in the Champions League to heap more pressure on boss Massimiliano Allegri.
Juve have now suffered back-to-back Group H defeats and face an uphill task to reach the knockout stage.
The hosts led through Arkadiusz Milik’s header but were pegged back by Joao Mario’s penalty.
David Neres scored the winner at Allianz Stadium as Juve slipped to defeat in their opening two Champions League group games for the first time.
Having been beaten by Paris St-Germain in their group opener last week and denied a winner against Salernitana amid a chaotic finale at the weekend, this defeat will only increase the dissatisfaction among some fans in Turin.
Juventus have won two of their opening six Serie A games this season and sit in eighth place, four points behind leaders Napoli.
Benfica, meanwhile, have won all 12 of their games this season, with a first victory in Italy since 1997 the latest.
They found the winner in the second half when Neres slotted home on the rebound after Mattia Perin parried an initial shot.
Juventus had earlier gone in front when Milik flicked in a free-kick, but were pegged back when Fabio Miretti was adjudged to have conceded a penalty following a VAR review.