Three countries from the region are in the last eight of the tournament designed exclusively for home-based players.
This comes after the conclusion of the group phase of the 16-team competition.
Hosts Cameroon, DR Congo and Congo are the countries from the UNIFFAC zone that have advanced to the knock-out stages of the CHAN tournament.
West Africa is the next with two countries as Guinea and Mali will be representing their bloc at the stage that will begin on Saturday.
Morocco will represent North Africa; Zambia will be the representatives of the southern African group while Rwanda will feature for the CECAFA region.
The other interesting bit is that every region on the continent is represented in the quarter-finals of the 2020 CHAN tournament.
The quarter-final will start on Saturday when Mali play Congo in Yaounde while DR Congo take on hosts Cameroon at the Japoma Stadium in Douala.
On Sunday, Morocco will take on Zambia in Douala at the Reunification Stadium while Guinea and Rwanda clash at the Limbe Stadium.